Cellular Energy & NAD+
Nicotinamide Riboside is a modern, highly bioavailable form of vitamin B3 that the body converts into NAD+ (nicotinamide adenine dinucleotide) — the molecule that regulates metabolism, energy, recovery, and cellular repair. NAD+ is essential for mitochondria to function and produce the cell’s vital energy. With age, NAD+ naturally declines significantly, leading to fatigue, slower recovery, and higher levels of cellular stress. NR is the most direct and purest source of NAD+, backed by leading clinical research.
What it does:
- Boosts NAD+ (cellular energy)
- Supports recovery enzymes
- Improves mitochondrial function
- Supports mental alertness and clarity
Synergies:
- NR + PQQ → dual mitochondrial activation
- NR + Q10 → more efficient cellular energy production
- NR + Resveratrol → activates key pathways for longevity
Coenzyme Q10 is a natural molecule found in all mitochondria — the “powerhouses” of cells. It plays a direct role in the process of converting nutrients into energy and supports cellular energy production (the biochemical power that allows cells to function). Q10 levels decline significantly with age, especially in organs with high energy demands such as the heart. In addition, Q10 is a powerful antioxidant that protects cell membranes from damage and supports endurance.
What it does:
- Participates in energy production
- Supports the cardiovascular system
- Provides strong antioxidant protection
- Improves endurance
Synergies:
- Q10 + NR → increased energy
- Q10 + PQQ → mitochondrial synergy
- Q10 + Vit C/E → antioxidant regeneration
PQQ (pyrroloquinoline quinone) is a vitamin-like molecule that plays a key role in supporting and protecting mitochondria. Mitochondria are the structures that convert food into energy; when they are weak or damaged, the entire body suffers. PQQ supports their efficiency, protects them from damage, and even stimulates processes related to the “birth” of new mitochondria. This affects energy, focus, endurance, and cellular resilience.
What it does:
- Improves mitochondrial efficiency
- Supports energy metabolism
- Helps with better focus and vitality
- Has antioxidant activity
Synergies:
- PQQ + NR → the most powerful duo for boosting cellular energy
- PQQ + Q10 → optimal mitochondrial function
Polyphenols for Longevity
Trans-resveratrol is the active form of resveratrol — a natural polyphenol found in grape skins and known as one of the most extensively studied molecules for longevity. It activates sirtuins (SIRT1) — a family of enzymes that regulate cellular aging, repair, and stress resistance. Resveratrol supports blood circulation by improving nitric oxide (NO) levels and vascular elasticity. It combines anti-inflammatory, antioxidant, and neuroprotective properties, making it a key component in longevity support systems.
What it does:
- Supports SIRT1 (cellular longevity)
- Improves blood circulation
- Has an antioxidant effect
- Supports brain function
Synergies:
- Resveratrol + NR → activation of cellular pathways for longevity
- Resveratrol + Apigenin → dual cellular protection
- Resveratrol + OPC → increased antioxidant activity
OPC (oligomeric proanthocyanidins) are among the most powerful natural antioxidants found in grape seeds. They have exceptionally high bioavailability and are rapidly absorbed, supporting the vascular system, collagen, and microcirculation. OPCs protect cell membranes from damage, stabilize capillaries, and support the health of the skin, joints, and brain. They are known to have antioxidant power up to 20 times higher than vitamin C, making them key for deep cellular protection.
What it does:
- Supports blood vessel health
- Protects the skin and collagen
- Powerful antioxidant
- Supports circulation
Synergies:
- OPC + Vit C → antioxidant regeneration
- OPC + Glycine → collagen support
- OPC + Astaxanthin → double protection for cell membranes
Apigenin is a bioflavonoid found in chamomile, parsley, and celery, known for its ability to support cellular balance and nervous system relaxation. It influences the enzyme CD38, which breaks down NAD+ — thus, apigenin indirectly helps maintain high NAD+ levels. In addition, apigenin supports natural cellular cleansing and autophagy processes, reduces oxidative stress, and helps the body adapt to daily stressors.
What it does:
- Helps preserve NAD+
- Supports natural cellular cleansing
- Calms the nervous system
- Has strong antioxidant activity
Synergies:
- Apigenin + NR → higher NAD+ levels
- Apigenin + Phisetin → cellular renewal
- Apigenin + Spermidine → autophagy
Fisetin is a polyphenol found naturally in strawberries, apples, onions, and cucumbers. It is known for its senolytic effect — it helps remove old, non-functional cells that accumulate with age and hinder normal tissue function. Fisetin also has a powerful antioxidant effect, supports neural communication, and may positively influence memory and mood. This makes it one of the most potent nutrients for cellular renewal and longevity support.
What it does:
- Supports cellular autophagy
- Has an antioxidant effect
- Supports cognitive function
- Reduces cellular stress
Synergies:
- Fisetin + Apigenin → a powerful combination for cellular renewal
- Fisetin + Spermidine → autophagy
- Fisetin + Resveratrol → cellular protection
Cognitive Matrix
CDP-Choline, also known as citicoline, is a natural molecule that serves as a precursor to acetylcholine — the neurotransmitter responsible for concentration, memory, and cognitive processing speed. In addition, CDP-Choline supports the synthesis of phosphatidylcholine, a key building block of nerve cell membranes. This improves communication between neurons and supports brain metabolism and energy balance. Citicoline is one of the most well-studied compounds in clinical research for supporting focus, memory, and mental endurance.
What it does:
- Improves concentration
- Supports memory
- Boosts brain energy
- Supports neuronal protection
Synergies:
- CDP-Choline + ALCAR → higher acetylcholine
- CDP-Choline + Uridine → better membranes
- CDP-Choline + B5 → energy
Uridine is a nucleotide — one of the building blocks of RNA and cell membranes—that is particularly important for the brain. It plays a role in the synthesis of phosphatidylcholine and synaptic connections, which supports neuroplasticity — the brain’s ability to form new connections and learn. Uridine also influences mitochondrial function in neurons, improving their energy efficiency. It is a key component in many scientific formulas for memory and cognitive function.
What it does:
- Supports synaptic plasticity
- Supports the nervous system
- Improves cognitive function
- Supports cellular regeneration
Synergies:
- Uridine + CDP → membrane synergy
- Uridine + Vitamin B complex → natural repair
- Uridine + DHA (in food) → membrane stability
L-Serine is an amino acid that plays a key role in brain metabolism. It is a precursor to D-serine — a molecule that supports the function of NMDA receptors, which are important for memory, learning, and neural communication. L-Serine also participates in the synthesis of phospholipids for cell membranes and myelin — the “insulation” of nerve fibers. This makes it critical for nervous system health, stress responses, and mental productivity.
What it does:
- Supports NMDA receptors
- Supports neuroplasticity
- Participates in myelin synthesis
- Supports brain function
Synergies:
- Serine + Glycine → neurotransmitters
- Serine + B6 → metabolic reactions
L-Theanine is an amino acid found in green tea, known for its ability to increase alpha brain waves — a pattern of neural activity characteristic of a calm yet focused state. It reduces nervous excitement by influencing GABA, serotonin, and dopamine. L-Theanine allows for clear concentration without nervousness or a drop in energy. It also supports sleep quality without causing daytime drowsiness.
What it does:
- Increases alpha waves (relaxation + focus)
- Reduces nervous tension
- Improves concentration
- Supports sleep
Synergies:
- Theanine + CDP → focus without nervousness
- Theanine + Magnesium → relaxation
Amino Acid Complex
Glycine is the simplest amino acid, but one of the most important: it accounts for about 33% of collagen’s structure, making it a key building block for skin, joints, tendons, and connective tissues. In addition, glycine is a major component of glutathione — the body’s internal antioxidant system, which protects cells from damage and supports liver detoxification. Glycine also plays a role in regulating the nervous system, promoting deep sleep, relaxation, and recovery. It is one of the purest and most functional amino acids for structural and cellular health.
What it does:
- Boosts collagen synthesis
- Supports liver detoxification
- Improves sleep and nervous system function
- Participates in glutathione synthesis (a major antioxidant)
Synergies:
- Glycine + Vitamin C → strong collagen synthesis
- Glycine + Magnesium → better sleep
- Glycine + Serine → neurotransmitters
Taurine is a conditionally essential amino acid found in high concentrations in the heart, brain, and skeletal muscles. It regulates mineral balance within cells, stabilizes cell membranes, and plays an important role in mitochondrial function. Taurine is particularly important for the cardiovascular system because it supports contractility, blood pressure, and electrolyte balance. It also reduces oxidative stress and supports the nervous system by improving relaxation and stress resilience.
What it does:
- Protects mitochondrial membranes
- Supports the cardiovascular system
- Regulates calcium in cells
- Supports the nervous system and relaxation
Synergies:
- Taurine + Q10 → stronger mitochondrial protection
- Taurine + ALCAR → energy production
- Taurine + Magnesium → relaxation and balance
ALCAR is an acetylated, highly bioavailable form of L-carnitine that easily crosses the blood-brain barrier. Its primary role is to transport fatty acids into the mitochondria, where they are converted into cellular energy. This makes ALCAR extremely valuable for the brain, muscles, and metabolism. It also plays a role in the production of acetylcholine, a key neurotransmitter for focus, memory, and mental speed. ALCAR improves mitochondrial function, reduces fatigue, and supports recovery.
What it does:
- Boosts energy production
- Supports acetylcholine (focus + memory)
- Improves endurance
- Supports brain function
Synergies:
- ALCAR + CDP-Choline → powerful focus and memory
- ALCAR + Q10 → higher energy production
- ALCAR + B5 → more Acetyl-CoA
Antioxidants & Balance
Astaxanthin is one of the most powerful natural antioxidants, extracted from red microalgae. It has a unique structure that allows it to protect cell membranes on both sides simultaneously—something most antioxidants cannot do. Astaxanthin protects the skin from UV damage, supports the eyes, brain, and cardiovascular system, and aids recovery after stress and exercise. It is known as the “king of antioxidants” because of its potency.
What it does:
- Powerful antioxidant
- Protects cells from UV damage
- Supports recovery
- Improves endurance
Synergies:
- Astaxanthin + Q10 → mitochondrial protection
- Astaxanthin + OPC → dual membrane protection
Spermidine is a natural polyamine that activates autophagy — the body’s internal process for “recycling” and clearing damaged cellular components. It is one of the key mechanisms associated with longevity, metabolic health, and cellular renewal. Spermidine supports the cardiovascular system, cellular balance, brain protection, and long-term health. It is considered one of the most important nutrients for longevity.
What it does:
- Supports autophagy
- Improves cellular balance
- Supports the cardiovascular system
- Supports long-term health
Synergies:
- Spermidine + Apigenin → double autophagy
- Spermidine + Fisetin → cellular synergy
- Spermidine + Resveratrol → longevity stack
Magnesium is one of the most important minerals in the human body and plays a role in over 300 enzymatic reactions related to energy production, the nervous system, muscle function, and detoxification. The bisglycinate form is chelated and highly bioavailable — it is bound to the amino acid glycine, making it gentler on the stomach and more bioavailable. Magnesium is necessary for the activation of vitamin D, for the balance of nerve impulses, and for a normal heart rhythm. It is one of the most basic yet critical minerals for daily energy and recovery.
What it does:
- Supports muscles and nerves
- Improves sleep and relaxation
- Participates in energy production
- Supports immunity and D3 activation
Synergies:
- Mg + D3 → proper activation
- Mg + Glycine → deeper sleep
- Mg + B-complex → better enzymatic reactions
Vitamin C is a key water-soluble antioxidant and one of the most important cofactors for collagen synthesis. It plays a role in the regeneration of other antioxidants (such as vitamin E), supports the immune system, and reduces cellular oxidative stress. In addition, vitamin C is essential for the normal function of white blood cells and for protecting the body against viruses and bacteria. It is a fundamental micronutrient for health, skin, immunity, and recovery.
What it does:
- Boosts the immune system
- Supports collagen
- Maintains antioxidant protection
- Supports cellular recovery
Synergies:
- Vit C + Glycine → collagen
- Vit C + OPC → dual antioxidant protection
- Vit C + D3/Zinc → immune synergy
Vitamin D3 is a hormone-like vitamin that plays a role in regulating the immune system, bone health, muscle strength, and hormonal balance. D3 regulates the absorption of calcium and phosphorus and influences mood and energy levels. A large portion of the population is deficient in D3 due to a lack of sunlight, which leads to fatigue, a weakened immune system, and bone problems. The combination of D3 + K2 + Mg is the gold standard for proper calcium metabolism.
What it does:
- Boosts the immune system
- Improves calcium absorption
- Supports mood and energy levels
- Maintains muscle strength
Synergies:
- D3 + K2 → proper calcium metabolism
- D3 + Magnesium → activation of D3
- D3 + Zinc → enhanced immune response
Vitamin K2 (especially the MK-7 form) is key to directing calcium to the right places — the bones and teeth, rather than the arteries. It activates proteins that prevent the calcification of blood vessels and maintain the elasticity of arterial walls. The MK-7 form is long-acting and the most bioactive, allowing for stable levels throughout the day. When properly combined with D3 and magnesium, K2 ensures optimal bone and cardiovascular balance.
What it does:
- Supports healthy arteries
- Strengthens bones
- Works together with D3
- Supports metabolic balance
Synergies:
- K2 + D3 → the perfect pair
- K2 + Magnesium → bone and metabolic synergy
Zinc is an essential mineral that plays a role in over 300 biological processes, including immunity, hormone synthesis (including testosterone), cell growth, and antioxidant protection. It supports the production of enzymes that protect cells from oxidative damage, maintains normal skin structure, and influences mood and metabolism. Zinc deficiency is widespread and often leads to a weakened immune system, hair loss, fatigue, and skin problems.
What it does:
- Boosts immunity
- Improves hormonal balance
- Supports skin and hair
- Plays a role in antioxidant enzymes
Synergies:
- Zinc + Vit C → immunity
- Zinc + B6 → hormones
- Zinc + D3 → strong immune response
High-Potency B-Complex
Vitamin B1 is an essential coenzyme involved in converting food into energy. It is necessary for the normal functioning of the nervous system, brain cells, and carbohydrate metabolism. Thiamine is critical for the creation of energy molecules that support energy levels, concentration, and nervous system stability.
What it does:
- Supports energy metabolism
- Supports the nervous system
- Participates in carbohydrate metabolism
- Supports brain function
Synergies:
- B1 + B2/B3 → improved energy metabolism
- B1 + Magnesium → effective enzyme activation
Riboflavin is a coenzyme that supports cellular energy production and is essential for maintaining antioxidant balance. It is important for the skin, eyes, and the normal utilization of other B vitamins. B2 plays a role in the cells’ internal “electricity”—the processes that provide energy in the mitochondria.
What it does:
- Supports energy production
- Supports fat and protein metabolism
- Supports skin and eye health
- Contributes to antioxidant protection
Synergies:
- B2 + NR/Q10 → higher mitochondrial efficiency
- B2 + B6/B9 → optimal metabolic activity
Niacin is one of the most essential vitamins for the production of NAD+—the molecule that drives energy, recovery, and cellular resilience. It participates in hundreds of biochemical reactions and supports the skin, circulatory system, and metabolism. B3 is the foundation of every cell’s energy cycle.
What it does:
- Supports cellular energy
- Supports skin and blood circulation
- Participates in the antioxidant system
- Supports metabolism
Synergies:
- B3 + NR → powerful NAD+ synergy
- B3 + Q10 → optimal ATP production
Vitamin B5 plays a role in the production of acetyl-CoA, one of the key molecules for energy, metabolism, and hormone production. It supports the stress response, the nervous system, and cell regeneration. B5 is necessary for fat utilization and for maintaining normal energy production.
What it does:
- Supports hormone synthesis
- Participates in the production of acetyl-CoA
- Supports metabolism and energy
- Helps with stress and fatigue
Synergies:
- B5 + ALCAR → a powerful acetyl-CoA production pathway
- B5 + the entire B-complex → metabolic harmony
Vitamin B6 is essential for the synthesis of neurotransmitters (serotonin, dopamine, GABA) and plays a central role in hormonal balance, mood, and the immune system. It aids in the breakdown of amino acids and participates in the formation of hemoglobin.
What it does:
- Supports the nervous system
- Improves hormonal balance
- Supports immune function
- Participates in amino acid metabolism
Synergies:
- B6 + Magnesium → calmness and better sleep
- B6 + Zinc → hormonal synergy
Biotin is the beauty vitamin—essential for healthy skin, hair, and nails. It plays a role in the metabolism of fatty acids, amino acids, and glucose. Biotin helps cells produce energy and maintain normal tissue structure.
What it does:
- Supports skin and hair
- Participates in energy production
- Supports fat metabolism
- Supports nails and tissues
Synergies:
- Biotin + B5 → skin + hair
- Biotin + Zinc → structure and regeneration
Folate is critical for cell division, the formation of new cells, blood formation, and genetic balance (methylation). It is particularly important for the brain, the nervous system, and tissue repair. Folate works in close cooperation with B12.
What it does:
- Supports blood formation
- Participates in DNA synthesis
- Supports the nervous system
- Supports methylation and cellular regeneration
Synergies:
- B9 + B12 → a powerful combination for blood and cells
- B9 + B6 → metabolic reactions
B12 is an essential vitamin for the nervous system, energy, metabolism, and blood. It supports DNA synthesis, nerve cells, and red blood cells. B12 deficiency is very common, especially among vegans, and leads to fatigue, brain fog, and nerve problems.
What it does:
- Strengthens the nervous system
- Supports energy
- Plays a role in methylation
- Supports blood formation
Synergies:
- B12 + B9 → healthy blood cells
- B12 + Magnesium → normal DNA synthesis
Roots™ • Ultimate Longevity Blend